Jun-Jie (Gogo) Liu

Associate professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University

junjiegogoliu(at)tsinghua.edu.cn

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Current Members

Pujuan Deng

Postdoc

Email: dengpj(at)mail.tsinghua.edu.cn

Research Topic:

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

Shouyue Zhang

Postdoc

Email: shouyuezhang(at)mail.tsinghua.edu.cn

Research Topic:

Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.

To explore the biological function and clinical therapeutic application of lncRNA.

Shuai Jin

Postdoc

Email: shuaijin(at)mail.tsinghua.edu.cn

Research Topic:

I) Directed evolution of the entire human or plant genomes.
II) Specificity of precise genome editing systems.
III) Evolutionary trajectory of CRISPR systems.

Yuanyuan Jiang

Postdoc

Email: jiangyyuan(at)mail.tsinghua.edu.cn

Research Topic:

(1) Exploring the mechanisms and biological functions of ribozymes;

(2) Developing novel RNA-based nucleic acid manipulation tools within animal and plant organisms.

Zheng Zhang

Postdoc

Email: zhengzhang61(at)mail.tsinghua.edu.cn

Research Topic:

Developing and optimizing RNA-based nucleic acid editing tools.
Editing is not manipulation but only guidance for the genome to fix itself.

Danyuan Li

Ph. D. Candidate

Email: li-dy18(at)mails.tsinghua.edu.cn

Research Topic:

I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA

Jingbo Jiang

Ph. D. Candidate - joint PhD. student

Email: jiangjb18(at)mails.tsinghua.edu.cn

Research Topic:

(1) Studying on physiological RNA substrate of RNA exosome complex in direct-access route by biochemistry and structure;
(2) Exploring new cofactors of RNA exosome complex in yeast and human cells and determining the complex structures.

Yun Yang

Ph. D. Candidate

Email: yangyun19(at)mails.tsinghua.edu.cn

Research Topic:

My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.

Mingzhe Xia

Ph. D. Candidate- joint PhD. student

Email: xmz19(at)mails.tsinghua.edu.cn

Research Topic:

(1) Study the mechanism of low phosphorus response and root hair development of Arabidopsis.
(2) Exploring the biochemical properties of plant transposase and their effects on biological functions.

Chengping Li

Ph. D. Candidate

Email: lcp20(at)mails.tsinghua.edu.cn

Research Topic:

Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.

Determining the 3D structures of proteins and RNAs using Cryo-EM.

Hanzhou Zhu

Ph. D. Candidate

Email: zhz20(at)mails.tsinghua.edu.cn

Research Topic:

I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.

Ao Sun

Ph. D. Candidate

Email: sunao20(at)mails.tsinghua.edu.cn

Research Topic:

1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools

Shunqing Tan

Ph. D. Candidate

Email: tansq21(at)mails.tsinghua.edu.cn

Research Topic:

Exploring the mechanism of nuclease activities and developing novel gene editing tools.

Zixian Liu

Ph. D. Candidate

Email: liuzx21(at)mails.tsinghua.edu.cn

Research Topic:

My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.

Longqi Li

Ph. D. Student

Email: lilq22(at)mails.tsinghua.edu.cn

Research Topic:

Detection of gene-editing potential of novel nucleases in mammalian cells and Development of the next-generation gene-manipulating toolbox.

Shuo Lin

Ph. D. Student

Email:lins23@mails.tsinghua.edu.cn

Research Topic:

Mining new ribozyme in matagenomic database and using structual biology approach to solve the mechenism

Gaoli Wang

Ph. D. Student

Email: wanggl23(at)mails.tsinghua.edu.cn

Research Topic:

Searching for ribozymes with novel functions and exploring their applications as biological tools

Shulin Jin

Ph. D. Student

Email: jsl23(at)mails.tsinghua.edu.cn

Research Topic:

Exploring the mechanism of novel RNA-involved nuclease system by using biochemistry methods.

Ruihan Zhang

Ph. D. Student

Email: ruihan-z23(at)mails.tsinghua.edu.cn

Research Topic:

Leverage bioinformatics and AI techs to integrate sequence, structure, and evolutionary information for developing next-generation gene editing tools

Zhonghao Zhang

Research assistant

Email: zhonghaozhang2022(at)163.com

I graduated from Ocean University of China with a master's degree. I am currently working as a research assistant. I am easy-going, sincere, ready to help others, serious and responsible for work.